This stand-alone 'Fast and Furious' film opens in London, England where a team of MI6 agents led by Hattie Shaw (Vanessa Kirby) storm a warehouse to retrieve a deadly virus called "The Snowflake". They are found by the super-enhanced Brixton Lore (Idris Elba). Because of his cybernetic augmentations, he is able to sense incoming attacks, which allows him to wipe the floor with all of the other agents. Hattie injects her right hand with the Snowflake and escapes from Brixton's sight. He grabs a radio and makes it seem as though Hattie is a traitor who took the virus for herself.Meanwhile, Luke Hobbs (Dwayne Johnson) and Deckard Shaw (Jason Statham) wake up in their own homes in Los Angeles and London. They go about their daily routines before later going to separate nightclubs to beat the crap out of dozens of goons before they each find one to interrogate. Both Hobbs and Shaw have heard about the super virus that has been going around, and they know it has been manufactured by a terrorist group called Eteon. Their respective goons fail to give them the info they want, so Hobbs tattoos "I Love Cops" on his forehead while Shaw leaves his guy dangling out a window.Hobbs has breakfast in a diner with his daughter Sam (Eliana Sua) when he is visited by an old friend/CIA agent Locke (Ryan Reynolds). He informs Hobbs about the Snowflake and just how serious of a threat it is. Although reluctant to help, Hobbs agrees to do so. At the same time, Shaw goes to visit his mother Magdalene, AKA "Queenie" (Helen Mirren), in prison. She tells him about Hattie's predicament and that he should reach out to her, but he doesn't think Hattie wants to see him. After leaving the prison, Shaw is approached by Agent Loeb (Rob Delaney) to also go after the Snowflake. This leads Hobbs and Shaw to come face-to-face once again with Locke and Loeb asking them to work together. Their response? "No FUCKING way!" After exchanging insults, the two begrudgingly agree to work together. The other agents track Hattie down for the guys to go after her.While Shaw goes to Hattie's booby-trapped home, Hobbs manages to find her on the streets. She fights Hobbs to get away, while Shaw is fought by agents trying to track Hattie. He beats them all across the room, while Hobbs manages to gain the upper hand and bring Hattie in.Hattie is taken back to the CIA headquarters for questioning by Hobbs. Shaw shows up and informs Hobbs that she is his sister. She tells them that she is carrying the virus, just before Brixton shows up and attacks. Shaw recognizes him as an old colleague that he supposedly killed years earlier. Brixton attempts to take Hattie with him by going down the building with a harness, but Hobbs and Shaw pursue. Hobbs slides down the harness to get rid of Brixton's goons before giving Hattie a chance to get away. Hobbs fights Brixton, only to discover he is no match for the superhuman. Shaw drives by to pick up Hobbs and Hattie, and Brixton chases after them on a motorcycle, but the heroes lose him after he crashes through a bus. The three then see that Eteon has manipulated the media into declaring them all fugitives and traitors. Hattie goes off to try and find Professor Andreiko (Eddie Marsan), the creator of the Snowflake and the one who can extract the virus from her. Hobbs shows that he was tracking Andreiko before the attack, and they manage to locate him at a newsstand.Brixton returns to Eteon's headquarters to get more juiced up. He speaks to Eteon's mysterious leader, who knows of both Hobbs and Shaw and wants Brixton to have them join Eteon.The trio talk to Andreiko, who says that he developed Snowflake for Eteon, but he left them after realizing their plan to use it on humanity and then force them to be fixed by Eteon. He tells them that the only way to get it out of Hattie is to kill her or extract it from her through a facility in the Ukraine. Shaw uses some of his own gear to help keep himself, Hattie, and Hobbs from being tracked or recognized. They head to Moscow using fake names, with Hobbs getting "Mike Oxmaul" and almost getting detained for it. While on the plane, Shaw tells Hobbs to back off of Hattie since he can tell that he is attracted to her. Hobbs taunts Shaw with the prospect of him hooking up with his sister, but their bickering wakes up the air marshal, Dinkley (Kevin Hart). He figures that the two are on a mission, and he bemoans his lack of action. Dinkley gives them his card for whenever they need something.In Moscow, the trio visit an old flame of Shaw's, Margarita, AKA Madame M (Eiza Gonzalez), who is the leader of an all-female crew of criminals that rob peoples homes. She provides them with weapons and gear that they need to storm the Eteon facility. Margarita then takes them to the facility where she makes it look like she is giving Hattie up to Brixton, who is already there after interrogating Andreiko. Hobbs and Shaw sneak their way around the place after dropping in from a jet. They encounter armed goons and proceed to pummel all of them in separate halls. They then use the unconscious goons to get inside, where they are greeted by dozens of armed Eteon agents. Both of them are captured and strapped to electrical cables for interrogation. Brixton tries to get them to join Eteon, with each additional shock coming closer to killing them. Hattie sneaks up on Brixton and almost kills him, but the gun she's holding requires an identity reader. Hobbs and Shaw get free, fight off more goons, and destroy the facility after retrieving the extraction device. Unfortunately, Brixton snaps Andreiko's neck and gets away again, and the device gets wrecked. Hobbs then figures out somewhere to lay low.The three travel to Samoa, Hobbs's childhood home where his estranged family lives. He returns to his mother Sefina (Lori Pelenisa Tuisano) and brothers Jonah (Cliff Curtis), Mateo (Roman Reigns), Timo (Josh Mauga), and Kal (John Tui), plus his three cousins. Jonah is especially dismayed to see Hobbs after his long absence. However, Sefina knows how urgent it is that the brothers help Hobbs out. They go to arm themselves as they prepare for Brixton and Eteon's goons to arrive, but Sefina has gotten rid of all their weapons. The plan then becomes that the family will fight Eteon with their bare hands and wits. Jonah fixes the device to start getting it out of Hattie.Brixton and Eteon are tracked as they make their way to the island. The Hobbs men stand ready for battle. The Eteon goons try to shoot them, but Hattie has disabled their guns. Fists begin to fly, bodies are thrown, and bones are broken as the agents are demolished by the Samoans. Brixton grabs Hattie and starts to escape on a helicopter. Hobbs and Shaw ride together while Jonah and the others follow. They hook their vehicles together like a train as Hobbs throws a hook onto the helicopter to bring it down. The helicopter crashes down below. Hobbs and Shaw face off against Brixton while Hattie has all of the Snowflake removed from her, and she kills Brixton's goon. Realizing he is just going to intercept their every move, Hobbs and Shaw resolve to fight him by having one of them take a hit while the other delivers a hit. This proves effective, as it causes Brixton's programming to overload. After witnessing his defeat, the Eteon leader deprograms Brixton's enhancements, and he dies before falling over the edge of the cliff. The unseen Eteon leader then speaks to Hobbs and Shaw, implying that they will see the two of them again.Afterwards, Shaw and Hattie go visit their mother in prison and leave her a cake that may contain something that will allow her to escape. Meanwhile, Hobbs decides to bring Sam to meet his family, as he has decided to stick around this time.During the credits, Locke contacts Hobbs again as he is fighting with other Eteon agents over another, possibly even more deadly virus. Locke also managed to stab a guy with a brick. In another scene, Hobbs gets Shaw back for the Moscow fake name by having the police get him and address him as "Hugh Janus". Shaw steps out but doesn't look like he's going to go quietly.