College seniors and lifelong friends Miller (Miles Teller), a fast-talking hedonist, and Casey (Skyler Astin), a nice guy and soon to be stockbroker, arrive at the college where their third BFF Jeff (Justin Chon) is a medical student. It's Jeff's 21st birthday and Miller is desperate to get his buddy blindingly drunk, and enjoy one last amazing night before they all start their adult lives. Jeff protests because his demanding father has orchestrated and important job interview in the morning, but soon enough the birthday boy relents and eventually gets so thoroughly hammered he can barely speak, which presents a problem when Miller and Casey can't remember where there buddy lives. The trio sets off one wild adventure to find anyone on campus who can tell them where Jeff lives so that they can get him ready for his big appointment..